Effect of blueberry ( Vaccinium virgatum ) extract on depressive‐like behavior and metabolic serum alterations in lipopolysaccharide‐challenged mice

• DOI: 10.1111/jfbc.13920
• Publication Date: 2021-09-12T18:08:03Z
• Authors: Solange Vega Cust...; Luiza Spohr; Natália Pontes Bona; Anita Avila Souza; Bernardo Moraes M...; Sara Keske; Karina Pereira Lu...; Fernando Lopez Alvez; Roselia Maria Spa...; Francieli Moro St...; Mayara Sandrielly...
• Keywords: Vaccinium

In the present study, we aimed to investigate protective effect of blueberry extract on behavioral, biochemical, and morphological changes in an experimental model lipopolysaccharide (LPS)-induced depressive behavior. Male Swiss mice were pretreated with vehicle, fluoxetine (20 mg/kg), or Vaccinium virgatum (100 mg/kg 200 mg/kg) for seven days. On day 7, animals administered LPS injection (0.83 vehicle. Pretreatment prevented LPS-induced depressive-like Moreover, increased serum levels total cholesterol; however, V. did not prevent increase cholesterol levels. Furthermore, elevation reactive oxygen species. Also, HDL Additionally, this decrease glucose adenosine deaminase activity. Collectively, has a potential against similar those observed patients depression. PRACTICAL APPLICATIONS: virgatum, popularly known as blueberry, been effective preventing treating neuropsychiatric diseases owing its antioxidant, anti-inflammatory, neuroprotective properties. Fluoxetine is drug used treat depression; adverse effects result therapeutic non-adherence. Thus, search new natural compounds possessing antidepressant activities while lacking crucial identifying novel alternatives