Laminarin ameliorates alcohol‐induced liver damage and its molecular mechanism in mice

• DOI: 10.1111/jfbc.14500
• Publication Date: 2022-12-14T10:47:31Z
• Authors: Tianyi Guo; Lingfeng Zhu; Yaping Zhou; Shuai Han; Yunyun Cao; Zuomin Hu; Yi Luo; Liyuan Bao; Xiuxiu Wu; Dandan Qin; Qinlu Lin; Feijun Luo
• Keywords: Laminarin

Alcoholic liver disease (ALD) has become a health issue globally. Laminarin, low molecular weight marine-derived β-glucan, been identified with multiple biological activities. In this study, the ameliorative effect on ALD of laminarin isolated from brown algae was investigated. Phenotypic, pathological alterations and biochemical characteristics indicated that administration (100 mg/kg/day) significantly alleviated injury improved function in alcohol-induced mice. Gene chip results treatment caused 52 up-regulated 13 down-regulated genes hepatic tissues damage mice, most these are associated regulation oxidative stress (such as CYP450/glutathione-dependent antioxidation), Wnt signaling pathway, retinol metabolism, cAMP pathway based GO KEGG analysis. PPI network analysis downstream target lied hub net. Our experiments also confirmed changed expressions some genes. Taken together, suggest can ameliorate mice its mechanism lies modulating anti-oxidation WNT which regulate alleviate damage. study provides new clue to prevent will be benefit develop functional foods. Practical applications This verified positive alcoholic laminarin, water-soluble algae-derived linked by β-(1,3) glycosidic bonds β-(1,6) branches. Laminarin Moreover, transcriptomics bioinformatics further revealed gene expression patterns, targets, signalings including CYP450/glutathione, Wnt, pathways regulated laminarin. research is first evidence for hepatoprotective against mechanism, advantage foods or adjuvant therapy ALD.