Effect of multispecies probiotics on irritable bowel syndrome: A randomized, double‐blind, placebo‐controlled trial

• DOI: 10.1111/jgh.12322
• Publication Date: 2013-07-05T11:46:42Z
• Authors: Jun Sik Yoon; Won Sohn; Oh Young Lee; Sang Pyo Lee; Kang Nyeong Lee; Dae Won Jun; Hang Lak Lee; Byung Chul Yoon; Ho Soon Choi; Won‐Seok Chung; Jae‐Gu Seo
• Keywords: Bloating; Placebo-controlled study; Bifidobacterium bifidum; Lactobacillus rhamnosus

Abstract Background and Aim The efficacy of treatment with multispecies probiotics on irritable bowel syndrome ( IBS ) symptoms the alterations gut microbiota in patients who have taken were investigated. Methods This randomized, double‐blind, placebo‐controlled trial involved 49 (probiotics: 25, placebo: 24) diagnosed according to R ome III criteria. Patients randomly assigned two groups: either receive (a mixture B ifidobacterium longum , . bifidum lactis L actobacillus acidophilus rhamnosus S treptococcus thermophilus twice a day for 4 weeks or placebo weeks. primary end‐point was proportion participants whose substantially relieved at week 4. Secondary end‐points intensity abdominal pain/discomfort, bloating, stool frequency/consistency, fecal microflora over Fecal analyzed 34 17, 17) by quantitative real‐time polymerase chain reaction assays. Results significantly higher group than group: 68.0% (17/25) versus 37.5% (9/24) P < 0.05). such as improvement pain/discomfort bloating occurred but not group. analysis revealed that had increased after Conclusions Multispecies are effective induce composition intestinal microbiota.