Advanced liver fibrosis by transient elastography, Fibrosis 4, and alanine aminotransferase/platelet ratio index among Asian hepatitis C with and without human immunodeficiency virus infection: Role of vitamin D levels

• DOI: 10.1111/jgh.12613
• Publication Date: 2014-04-14T12:11:05Z
• Authors: Anchalee Avihings...; Salyavit Jitmitra...; Pisit Tangkijvanich; Reshmie A. Ramaut...; Tanakorn Apornpong; Supunee Jirajariy...; Opass Putcharoen; Sombat Treepraser...; Srunthron Akkarat...; Yong Poovorawan; Gail V Matthews; Joep MA Lange; Kiat Ruxrungtham
• Keywords: Transient elastography; Hepatitis C

Vitamin D insufficiency plays an important role in liver fibrosis hepatitis C virus (HCV)-infected patients. We assessed by transient elastography and 25 hydroxy vitamin [25(OH)D] status HCV-infected patients, with (HIV/HCV) or without HIV co-infection (HCV) from Thailand.Fibrosis stage was defined as mild (< 7.1 kPa); moderate (7.2-9.4 severe (9.5-14 kPa), cirrhosis (> 14 kPa). Hypovitaminosis 25(OH)D < 30 ng/mL. Logistic regression analyses were used to assess predictors for significant fibrosis. Serum 25(OH) levels, HCV genotypes (GT), interleukin-28B (IL28B) HCV-RNA assessed.A total of 331 130 HIV/HCV patients enrolled (70% male, 35% people who inject drugs [PWIDs]). GT distribution follows: GT3 47%, GT1 34%, GT6 17%. IL-28B CC genotype (rs12979860) found 88% 85% HCV. In HCV, 56.5%; 18.4%; 12.4%; 12.7%. HIV/HCV, these figures 30.6%, 27.8%, 17.6%, 24.1%, respectively. Patients more often older, infection, hypovitaminosis D, less likely be infected GT6. Factors associated multivariate analysis infection (adjusted odd ratio [95% confidential interval]: 2.67, 1.20-5.93), P = 0.016, Fib-4 score > 1.45 (6.30, 2.70-14.74), 0.001, (2.48, 1.09-5.67), 0.031. 6 have advanced (0.17, 0.05-0.65), 0.01.HIV 1.45, are strong independent the presence our These data highlight urgent need treatment supplement resource-limited settings.