Role of SSH1 in colorectal cancer prognosis and tumor progression

• DOI: 10.1111/jgh.15001
• Publication Date: 2020-02-05T03:31:19Z
• Authors: Xiangping Song; Di Xie; Xiao Xia; Fengbo Tan; Qian Pei; Yuqiang Li; Zhongyi Zhou; Yuan Zhou; Chenglong Li; Kangtao Wang; Haiping Pei
• Keywords: Tumor progression

Slingshot 1 protein (SSH1) plays a critical role in cytoskeleton dynamic regulation. Increasing evidence suggest that SSH1 expression is upregulated several cancers and relates to tumor progression drug resistance. Here, we evaluated the of colorectal cancer (CRC) development its prognostic value patients with CRC.SSH1 was examined by quantitative real-time polymerase chain reaction, western blot analysis, or immunohistochemistry. The association between clinical characteristics prognosis evaluated. Stable knockdown cells were used for vitro assays xenograft models. Correlation epithelial-mesenchymal transition (EMT) analyzed online data analysis.SSH1 tissue compared paired non-cancerous CRC. level CRC associated stage, lymph node metastasis, correlated poor as indicated univariate multivariate analyses. In vitro, loss impaired colony formation, migration, invasion cells. vivo could promote metastasis Interestingly, E-cadherin, ZEB1, Snail, which are markers EMT, had significant correlation SSH1.SSH1 predicts prognosis. may regulating EMT.