Metabolic associated fatty liver disease increases coronavirus disease 2019 disease severity in nondiabetic patients

• DOI: 10.1111/jgh.15112
• Publication Date: 2020-05-21T12:18:31Z
• Authors: Feng Gao; Kenneth I Zheng; Xiao‐Bo Wang; Hua‐Dong Yan; Qing‐Feng Sun; Ke‐Hua Pan; Ting‐Yao Wang; Yong‐Ping Chen; Jacob George; Ming‐Hua Zheng
• Keywords: Adult; Male; China; Hepatology; Adolescent; Gastroenterology; 610; COVID-19; Middle Aged; Severity of Illness Index; 3. Good health; Coronavirus; Cohort Studies; Fatty Liver; Young Adult; 03 medical and health sciences; Logistic Models; 0302 clinical medicine; Risk Factors; Case-Control Studies; Humans; Female; Aged

Coronavirus disease 2019 (COVID-19) has attracted increasing worldwide attention. While diabetes is known to aggravate COVID-19 severity, it not whether nondiabetic patients with metabolic dysfunction are also more prone severe disease. The association of associated fatty liver (MAFLD) severity in was investigated here.The study cohort comprised 65 (i.e. cases) and without MAFLD controls). Each case randomly matched one control by sex (1:1) age (±5 years). between the presence (as exposure) outcome) assessed binary logistic regression analysis.In COVID-19, a four-fold increased risk COVID-19; numbers factors. persisted after adjusting for age, sex, coexisting morbid conditions.Health-care professionals caring should be cognizant likelihood MAFLD.