Prevalence of serrated lesions, risk factors, and their association with synchronous advanced colorectal neoplasia in asymptomatic screened individuals

• DOI: 10.1111/jgh.15116
• Publication Date: 2020-05-22T09:45:04Z
• Authors: Masau Sekiguchi; Yasuo Kakugawa; Minori Matsumoto; Keiko Nakamura; Yasuhiko Mizuguchi; Hiroyuki Takamaru; Masayoshi Yamada; Taku Sakamoto; Yutaka Saito; Takahisa Matsuda
• Keywords: Adult; Aged, 80 and over; Male; Age Factors; Colonoscopy; Middle Aged; Body Mass Index; 3. Good health; Neoplasms, Multiple Primary; 03 medical and health sciences; Logistic Models; 0302 clinical medicine; Japan; Asymptomatic Diseases; Prevalence; Humans; Female; Colorectal Neoplasms; Medical History Taking; Early Detection of Cancer; Aged; Neoplasm Staging; Quality of Health Care

Abstract Background and Aim Serrated lesions (SLs) have attracted attention as precursors of colorectal cancer (CRC). However, their prevalence, risk factors, clinical significance not been satisfactorily elucidated. This study used high‐quality colonoscopy data to determine the prevalence SLs identify factors relationship with synchronous advanced neoplasia (ACN) in asymptomatic screened individuals. Methods included for 5218 individuals who underwent first‐time screening by highly experienced endoscopists. The relationships between baseline characteristics presence those ACN were assessed using chi‐squared test multivariate logistic regression. Results proportions right‐sided 23.3% 7.6%, respectively. Age, sex, family history CRC, smoking, body mass index significantly related SLs, current smoking was most strongly associated (adjusted odds ratio [aOR] 2.6, 95% confidence interval [CI] 2.1–3.2). aOR (95% CI) sized ≥ 10 mm, 5 mm 1.4 (1.1–1.9), 3.5 (1.3–9.6), 1.9 (1.0–3.8), left‐sided (without SLs) also (aOR 8.1, CI 2.0–33.7). Conclusions relatively high elucidated significant particularly confirmed.