Skeletal muscle atrophy is exacerbated by steatotic and fibrotic liver‐derived TNF‐α in senescence‐accelerated mice

• DOI: 10.1111/jgh.16171
• Publication Date: 2023-03-09T03:39:26Z
• Authors: Yohei Shirakami; Junichi Kato; Toshihide Maeda; Takayasu Ideta; Kenji Imai; Hiroyasu Sakai; Makoto Shiraki; Masahito Shimizu
• Keywords: Steatohepatitis; Senescence; Muscle Atrophy

Although liver diseases, including non-alcoholic steatohepatitis, are associated with skeletal muscle atrophy, the mechanism behind their association has not been fully elucidated. In this study, effects of aging and steatohepatitis on muscle, interaction between were investigated using a diet-induced model in senescence-accelerated mice.A total four groups mice control fed either steatohepatitis-inducing or diet, livers muscles removed for examinations.In senescence-accelerated/non-alcoholic group, serum level alanine aminotransferase was markedly elevated histopathology significant. Skeletal also atrophied. The expression ubiquitin ligase Murf1 significantly increased while that Tnfa different. contrast, hepatic TNF-α levels group. These results suggest liver-derived might promote atrophy through Murf-1. metabolomic analysis indicated higher spermidine lower tryptophan steatohepatitis-diet group.The findings study revealed an aspect liver-muscle interaction, which be important developing treatments sarcopenia diseases.