The improvement of intestinal dysbiosis and hepatic metabolic dysfunction in dextran sulfate sodium‐induced colitis mice: effects of curcumin

• DOI: 10.1111/jgh.16205
• Publication Date: 2023-05-21T06:40:41Z
• Authors: Feini Zhou; Ting Mai; Ziren Wang; Zhaolong Zeng; Jingjing Shi; Fan Zhang; Ning Kong; Hao Jiang; Lingnan Guo; Maosheng Xu; Jiangnan Lin
• Keywords: Dysbiosis; Deoxycholic acid

Abstract Background and Aim Curcumin may have promising application in the prevention amelioration of inflammatory bowel disease (IBD). However, underlying mechanisms underpinning ability curcumin to interact with gut liver IBD remains be defined, which is exploration aim this study. Methods Mice dextran sulfate sodium salt (DSS)‐induced acute colitis were treated either 100 mg/kg or phosphate buffer saline (PBS). Hematoxylin–eosin (HE) staining, 16S rDNA Miseq sequencing, proton nuclear magnetic resonance ( 1 H NMR) spectroscopy, liquid chromatography–tandem mass spectrometry (LC‐MS/MS) applied for analysis. Spearman's correlation coefficient (SCC) was utilized assess between modification intestinal bacteria hepatic metabolite parameters. Results supplementation not only prevented further loss body weight colon length mice but also improved diseases activity index (DAI), colonic mucosal injury, infiltration. Meanwhile, restored composition microbiota, significantly increased Akkermansia , Muribaculaceae_unclassified Muribaculum elevated concentration propionate, butyrate, glycine, tryptophan, betaine intestine. For metabolic disturbances, intervention altered 14 metabolites, including anthranilic acid 8‐amino‐7‐oxononanoate while enriching pathways related metabolism bile acids, glucagon, amino biotin, butanoate. Furthermore, SCC analysis revealed a potential upregulation probiotics alterations metabolites. Conclusion The therapeutic mechanism against occurs by improving dysbiosis disorders, thus contributing stabilization gut–liver axis.