Coffee and caffeine intake reduces risk of ulcerative colitis: a case–control study in Japan

• DOI: 10.1111/jgh.16439
• Publication Date: 2023-12-11T05:34:20Z
• Authors: Keiko Tanaka; Hitomi Okubo; Yoshihiro Miyake; Chisato Nagata; Shinya Furukawa; Akira Andoh; Tetsuji Yokoyama; Naoki Yoshimura; Kenichiro Mori; Tomoyuki Ninomiya; Yasunori Yamamoto; Eiji Takeshita; Yoshio Ikeda; Mitsuru Saito; Katsuhisa Ohashi; Hirotsugu Imaeda; Kazuki Kakimoto; Kazuhide Higuchi; Hiroaki Nunoi; Yuji Mizukami; Seiyuu Suzuki; Sakiko Hiraoka; Hiroyuki Okada; Keitarou Kawasaki; Masaaki Higashiyama; Ryota Hokari; Hiromasa Miura; Teruki Miyake; Teru Kumagi; Hiromasa Kato; Naohito Hato; Koji Sayama; Yoichi Hiasa

AbstractBackground and AimAlthough diet is one of the potential environmental factors affecting ulcerative colitis (UC), evidence is not sufficient to draw definitive conclusions. This Japanese case–control study examined the association between the consumption of coffee, other caffeine‐containing beverages and food, and total caffeine and the risk of UC.MethodsThe study involved 384 UC cases and 665 control subjects. Intake of coffee, decaffeinated coffee, black tea, green tea, oolong tea, carbonated soft drinks, and chocolate snacks was measured with a semiquantitative food‐frequency questionnaire. Adjustments were made for sex, age, pack‐years of smoking, alcohol consumption, history of appendicitis, family history of UC, education level, body mass index, and intake of vitamin C, retinol, and total energy.ResultsHigher consumption of coffee and carbonated soft drinks was associated with a reduced risk of UC with a significant dose–response relationship (P for trend for coffee and carbonated soft drinks were <0.0001 and 0.01, respectively), whereas higher consumption of chocolate snacks was significantly associated with an increased risk of UC. No association was observed between consumption of decaffeinated coffee, black tea, green tea, or oolong tea and the risk of UC. Total caffeine intake was inversely associated with the risk of UC; the adjusted odds ratio between extreme quartiles was 0.44 (95% confidence interval: 0.29–0.67; P for trend <0.0001).ConclusionsWe confirmed that intake of coffee and caffeine is also associated with a reduced risk of UC in Japan where people consume relatively low quantities of coffee compared with Western countries.