Inhibition of striatal‐enriched tyrosine phosphatase 61 in the dorsomedial striatum is sufficient to increased ethanol consumption

• DOI: 10.1111/jnc.12701
• Publication Date: 2014-03-03T11:46:21Z
• Authors: Emmanuel Darcq; Sami Ben Hamida; Su Wu; Khanky Phamluong; Viktor Kharazia; Jian Xu; Paul Lombroso; Dorit Ron
• Keywords: FYN

Abstract The ST riatal‐Enriched protein tyrosine Phosphatase 61 ( STEP ) inhibits the activity of kinase Fyn and dephosphorylates GluN2B subunit NMDA receptor, whereas A phosphorylation phosphatase (Pharmacol. Rev. , 64, p. 65). Previously, we found that ethanol activates in dorsomedial striatum DMS leading to phosphorylation, which, turn, underlies development intake J. Neurosci., 30, 10187). Here, tested hypothesis inhibition by is upstream Fyn/GluN2B. We show exposure mice increased which was maintained after withdrawal not observed other striatal regions. Specific knockdown enhanced ethanol‐mediated activation without altering level water, saccharine, quinine consumption or spontaneous locomotor activity. Together, our data suggest blockade response sufficient for Fyn/GluN2B pathway . Being GluN2B, inactive primes induction intake. image leads phosphorylation. (a) Under basal conditions, active GluN2B. (b) Ethanol on a specific inhibitory site. contributes ethanol, phosphorylates These molecular adaptations promote drinking.