miR‐144‐3p exerts anti‐tumor effects in glioblastoma by targeting c‐Met

• DOI: 10.1111/jnc.13272
• Publication Date: 2015-08-06T14:38:54Z
• Authors: Fengming Lan; Huiming Yu; Man Hu; Tingyi Xia; Xiao Yue
• Keywords: Tensin; Temozolomide; U87

The study aimed to explore the specific function and mechanism of miR-144-3p in glioblastoma (GBM) cells with different phosphatase tensin homolog (PTEN) phenotypes. We demonstrated that level was significantly down-regulated glioma compared non-neoplastic brain tissues, decreased ascending grades. loss effectively predicted overall survival patients. Interestingly, expression MET up-regulated inversely associated tissues. Next, we certified specifically bound 3'-untranslated region (3' UTR) inhibited its expression. potently repressed GBM cell proliferation invasion via suppressing vitro vivo. In addition, our results showed no difference malignancy inhibition induced by PTEN several signaling pathways targeting independent status cells. Over-expression capability increased apoptosis, resulting enhancement radiation temozolomide sensitivity. Our data provide new insights into potential application therapy then inhibiting downstream signaling.