The ameliorative effect of fluoxetine on neuroinflammation induced by sleep deprivation

• DOI: 10.1111/jnc.14272
• Publication Date: 2017-12-09T15:17:03Z
• Authors: Maosheng Xia; Xiaowei Li; Li Yang; Jiaan Ren; Guangfeng Sun; Shuang Qi; Alexei Verkhratsky; Baoman Li
• Keywords: Sleep; Privation

It is well known that sleep disorders are harmful to people's health and performance, growing evidence suggests deprivation (SD) can trigger neuroinflammation in the brain. The nucleotide-binding domain leucine-rich repeat protein-3 (NLRP3) inflammasome reported be relevant induced by SD, but regulatory signaling governs NLRP3 SD still unknown. Meanwhile, whether action of antidepressants astrocytes could affect also remains obscure. In this study, we were first discover antidepressant fluoxetine, a type specific serotonin reuptake inhibitor widely used clinical practice, suppress neuronal apoptosis SD. main findings from study as follows: (i) stimulated expression activated inflammasomes maturation IL-1β/18 via suppressing phosphorylation STAT3 astrocytes; (ii) decreased activation AKT GSK-3β, which inhibited STAT3; (iii) was partly mediated P2X7 receptor; (iv) an agonist significantly abolish receptor primary cultured (v) administration fluoxetine reverse stimulation function through elevating STAT3. conclusion, our present research promising possibility ameliorate impairment