Regulation of T‐type Ca2+ channel expression by interleukin‐6 in sensory‐like ND7/23 cells post‐herpes simplex virus (HSV‐1) infection

• DOI: 10.1111/jnc.14697
• Publication Date: 2019-03-20T03:48:30Z
• Authors: Qiaojuan Zhang; Shao‐Chung Hsia; Miguel Martin‐Car...
• Keywords: 0301 basic medicine; Interleukin-6; Gene Expression; Herpes Simplex; Herpesvirus 1, Human; 3. Good health; Rats; Calcium Channels, T-Type; Mice; 03 medical and health sciences; Cell Line, Tumor; Animals; Humans

Herpes simplex virus-type 1 (HSV-1) infection of sensory neurons may lead to a significant reduction in the expression voltage-activated Na+ and Ca2+ channels, which can disrupt transmission pain information. Viral also results secretion various pro-inflammatory cytokines, including interleukin (IL)-6. In this work, we tested whether IL-6 regulates channels post-HSV-1 ND7/23 sensory-like neurons. Our demonstrate that HSV-1 causes decrease protein Cav3.2 T-type channel subunit, despite increasing mRNA synthesis. Neither nor total content was affected by treatment infection. cells, caused within 48 h. Exposure cells for 24 h post-infection reverses effect HSV-1, resulting increase current density. However, currents were not restored 24-h with cells. The ability functional on membrane blocked inhibition trafficking brefeldin-A ERK1/2 activation. These indicate release following alter