Social cognition and real‐life functioning in patient samples with 22q11.2 deletion syndrome with or without psychosis, compared to a large sample of patients with schizophrenia only and healthy controls

• DOI: 10.1111/jnp.12322
• Publication Date: 2023-05-10T21:40:33Z
• Authors: Marianna Frascarelli; Tommaso Accinni; Antonino Buzzanca; Luca Carlone; Francesco Ghezzi; Antonella Moschillo; Georgios D. Kotza...; Paola Bucci; Giulia Maria Gior...; Martina Fanella; Carlo Di Bonaventura; Carolina Putotto; Bruno Marino; Massimo Pasquini; Massimo Biondi; Fabio Di Fabio
• Keywords: Neurocognitive

Patients with the 22q11.2 deletion syndrome (DS) show an increased risk of developing a psychotic illness lifetime. 22q11.2DS may represent reliable model for studying neurobiological underpinnings schizophrenia. The study social inference abilities in genetic condition at high psychosis, like 22q11.2DS, shed light on relationships between neurocognitive processes and patients' daily general functioning. sample consisted 1736 participants, divided into four groups: patients diagnosis disorder (DEL SCZ, N = 20); subjects no psychosis (DEL, 43); diagnosed schizophrenia without (SCZ, 893); healthy controls (HC, 780). Social cognition was assessed through Awareness Inference Test (TASIT) functioning Specific Levels Functioning (SLoF) scale. We analysed data regression analysis. SCZ DEL groups had similar levels global functioning; they both significantly lower SLoF Total scores than HC (p < .001); group showed compared to other p .004; DEL, .003; HC, .001). A significant deficit observed three clinical groups. In groups, TASIT predicted .05). Our findings psychosis-prone point possible future adoption rehabilitation programmes, Skills Training Cognitive Remediation, during premorbid stages psychosis.