Home monitoring of maintenance intravenous immunoglobulin therapy in patients with chronic inflammatory neuropathy

• DOI: 10.1111/jns.12396
• Publication Date: 2020-05-29T16:47:53Z
• Authors: Pietro Emiliano D...; Daniele Mandia; Francesco Gentile; Francesca Gallia; Giuseppe Liberatore; Fabrizia Terenghi; Marta Ruiz; Eduardo Nobile‐Or...
• Keywords: Multifocal motor neuropathy; Maintenance therapy

Abstract To evaluate the utility of different outcome measures to monitor dose adjustment intravenous immunoglobulin (IVIg) therapy in patients with chronic inflammatory neuropathy (CIN). We assessed IVIg maintenance 20 (10 CIDP and 10 MMN) by regularly monitoring grip strength (GS) using a Martin Vigorimeter, RODS, quality life SF‐36 questionnaire. These were performed patient at home. also extended MRC sumscore (eMRC sumscore) each outpatient visit for infusion. enrolled 30 healthy controls measure any possible training effect GS time analyze random fluctuation GS. Clinically relevant change was detected eMRC 14 (93%) patients, RODS 11 (73%) 8 (53%) patients. Early sensitivity greatest (73%), followed (53%), (27%). This differed from CIDP, an early 100% MMN 75%. None alone sufficient detect clinically significant changes all Home objectively assisted clinical decision during individualization treatment. recommend multimodal approach individual CIN.