Administration of skin care regimens containing β‐glucan for skin recovery after fractional laser therapy: A split‐face, double‐blinded, vehicle‐controlled study

• DOI: 10.1111/jocd.13798
• Publication Date: 2020-10-31T12:44:58Z
• Authors: Yajing Cao; Peiru Wang; Guolong Zhang; Chan Hu; Haiyan Zhang; Xiuli Wang
• Keywords: Transepidermal water loss

Abstract Background Laser therapies have brought dawn to refractory skin diseases, but also were accompanied by postlaser inflammation and barrier dysfunction. To recover function quickly, the research development of active ingredients including β‐glucan for repair attracted much attention. Aims evaluate efficacy tolerance care regimens containing (Dermdoc®;Songyang Biotech) in repairing dysfunction after fractional laser therapy. Methods A total 20 patients with facial atrophic acne scars who accepted therapy recruited: 10 treated ablative CO2 1565nm nonablative laser. Using method split‐face vehicle‐control study, left half face was served as treatment side regimens, right control vehicle. Noninvasive bioinstrumentation hydration index, transepidermal water loss (TEWL), hemoglobin index (E value) detected study. Standard digital photographs taken at each visit. The adverse effect evaluated subject questionnaire. Results Compared side, Hemoglobin improved more significantly on 7th day ( P < .05). better than that 14th After treatment, TEWL statistically lower In self‐assessment questionnaires, 63.2% thought well tolerated without obvious reactions. Conclusion may play a positive role accelerating recovery