TNF‐α gene ‐238G>A polymorphism is associated with psoriasis patients

• DOI: 10.1111/jocd.14940
• Publication Date: 2022-03-27T13:44:42Z
• Authors: Raziye Akcılar; Nazlı Dizen Namdar; Fulya Yükcü; Selve Arslan Utku
• Keywords: Male; 03 medical and health sciences; Polymorphism, Genetic; 0302 clinical medicine; Tumor Necrosis Factor-alpha; Case-Control Studies; Humans; Psoriasis; Genetic Predisposition to Disease; Promoter Regions, Genetic; 3. Good health

AbstractBackgroundTumor necrosis factor‐alpha (TNF‐α) is a protein that plays a key role in the pathophysiology of chronic inflammatory disorders like psoriasis.AimsThe goal of this study was to see whether the TNF‐α gene ‐238G>A polymorphism was linked to psoriasis susceptibility.MethodsThis study comprised 90 psoriasis patients and ninety healthy controls. For the TNF‐α gene ‐238G>A polymorphism, genomic DNA was extracted and genotyped using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) studies.ResultsPsoriasis patients had higher frequencies of the A allele and the AA genotype than the control group, and psoriasis was linked to the AA genotype (OR = 4.25, 95% CI = 1.37–13.1, p = 0.008) and the A allele (OR = 1.55, 95% CI = 1.01–2.34, p = 0.04). Patients with a family history of psoriasis showed an increase in the frequency of the AA genotype compared with GG and GA genotypes (46.7%, 36.7%, and 16.7%, p = 0.003, respectively). Furthermore, psoriasis patients with the AA genotype were discovered more commonly among those under 30 years of age and male patients than those with the GG and GA genotypes, but the differences were not statistically significant.ConclusionThe TNF‐α gene ‐238G>A polymorphism has been related to an increased incidence of psoriasis.