Investigating the impact of added Profhilo mesogel to subcision versus subcision monotherapy in treating acne scars; a single‐blinded, split‐face randomized trial

• DOI: 10.1111/jocd.16258
• Publication Date: 2024-03-02T07:13:19Z
• Authors: Mani Dastgheib; Sama Heidari; Arghavan Azizipour; Mohammadreza Kavyani; Vahide Lajevardi; Amir Hooshang Ehsani; Amir Teimourpour; Maryam Daneshpazhooh; Mansour Nassiri K...; Kamran Balighi
• Keywords: Acne scars

Abstract Background Acne scar is an inflammatory condition, which commonly occurs in patients with acne vulgaris, especially adults. Mesogels have been reported effective improving atrophic scars. Aims We investigated the efficacy of adding Profhilo (a hyaluronic acid‐based filler) to subcision as a new treatment method. Methods Twelve aged 18–45 years scars on both sides face participated this single‐blinded, split‐face, randomized controlled trial. Each side was randomly assigned one methods, including alone and + Profhilo. Patients arm received mesogel (1 cc) addition procedure. Both methods were carried out two times at 1‐month intervals. Assessments done based sonographic depth scars, blinded observers examined photographs baseline 3 months after final session results exclusively made formula total score. The Global Improvement Scale Visual Analogue (VAS) (for patient satisfaction) also used. Results VAS score satisfaction statistically significant arm, mean improvement 528.08 219.06 ( p = 0.02). No difference seen reduction comparing (29.74 22.27 0.56). Sonographic non‐significant, 29.21 28.53 0.4). global four arms, no statistical significance observed 0.89). best response belonged rolling subtype 0.029 for 0.001 arm). Conclusion Despite between more due higher rate better physiologic effects.