Prospective randomized double‐blind comparative study of topical acetyl zingerone with tetrahexyldecyl ascorbate versus tetrahexyldecyl ascorbate alone on facial photoaging

• DOI: 10.1111/jocd.16292
• Publication Date: 2024-03-25T08:59:21Z
• Authors: Nasima Afzal; Nhi Nguyen; Mildred Min; Caitlin Egli; Shabnam Afzal; Ratan K. Chaudhuri; Waqas A. Burney; Raja K. Sivamani
• Keywords: Wrinkle; Photoaging; Erythema; Tolerability

Abstract Background Tetrahexydecyl ascorbate (THDA) is a lipophilic precursor to ascorbic acid that may be stabilized by acetyl zingerone (AZ). Studies have shown the topical application of THDA photoprotective effects. Similarly, AZ has been mitigate oxidative and inflammatory stress, thereby improving appearance photoaging. Aims To examine effects (THDA‐AZ) on skin photoaging compared alone. Patients/Methods In this double‐blind, randomized controlled trial, healthy individuals aged 30 65 were included 44 participants receive either THDA‐AZ (THDA 5% + 1%) or only 5%) for 8 weeks. Facial photographs taken at 0, 4, weeks analyze wrinkle severity, pigment intensity, redness intensity. A colorimeter was used assess infraorbital pigmentation erythema. Self‐perception tolerability assessed through questionnaires. Results Average severity significantly decreased in group Weeks 4 0.75% ( p = 0.023) 3.72% 0.048), respectively, where increased 7.88% 4.48%, respectively. intensity 4.10% 0.0002) Week 0.69% decrease group. 3.73% 0.0162) 14.25% 0.045), erythema 27.5% 8.34%, There no significant differences Conclusions Daily use combined improve facial greater extent than THDA. While alone increases erythema, addition reduces both.