T‐PRP‐DAT Gel: A Novel Material Promotes Adipose Tissue Regeneration

• DOI: 10.1111/jocd.70045
• Publication Date: 2025-02-18T08:54:16Z
• Authors: Mengmeng Hou; Jiezhang Tang; Yajie Guo; Han Peng; Baoyan Liang; Yi Cheng; Zhaoxiang Zhang; Siming Wei; Chenggang Yi; Huichen Li
• Keywords: Decellularization

ABSTRACT Background Decellularized adipose tissue (DAT) has emerged as a promising tissue‐specific regenerative platform for soft augmentation and reconstruction. Hydrogels are widely used DAT scaffold format their injectability porous structure. While unstable structure poor vascularization limit the regeneration of gels, this yields significant clinical necessity solutions to problem. Methods Based on collagen‐fibrin interpenetrating, we developed an injectable thermosensitive DAT/PRP interpenetrating polymer network (t‐DP gel/t‐DPI) with composition temperature‐controlled platelet‐rich plasma (t‐PRP). The same volume t‐DP gel were transplanted in mouse model, graft volume, weight, rate, compared. Results t‐DPI showed reinforced stability (IPN) sustained release growth factors from t‐PRP, resulting improved regeneration, vascularization. Conclusions Compared traditional gel, promotes by promoting angiogenesis stability, great potential future applications field plastic surgery its simple preparation ability.