Micro‐RNA gene expressions during cardiopulmonary bypass

• DOI: 10.1111/jocs.15329
• Publication Date: 2021-01-23T10:39:04Z
• Authors: Perfusionist Tüla...; Mustafa Göz; Nazım Kankılıç; Mehmet Salih Aydın; İsmail Koyuncu
• Keywords: Pathophysiology; Extracorporeal circulation

Introduction Cardiopulmonary bypass (CBP) is the most widely used method in cardiac surgery. During CPB procedure, studies are conducted to maintain myocardial perfusion adequacy, reduce oxidative stress caused by immune reactions, and understand longevity of procedure. Recently, microRNAs (miRNAs) have come fore changes CPB. In vivo shown that many different miRNAs regulate critical signaling molecules including cytokines, growth factors, transcription proapoptotic, antiapoptotic proteins. Our study aims investigate miR-34a, miR-15a, miR-320a gene expression extracorporeal circulation. Methods Fifteen patients who underwent elective open-heart surgery were included study. Serum plasma samples taken from preoperatively, at time CPB, 24 h postoperatively. Gene was studied. Differences compared. Results miR-15a increased during compared with preoperative levels (p < .001). This increase decreased after operation .05). miR-34a significantly .01). Similar other two expressions, Conclusions may play a key role initiation maintenance pathophysiological cascades showed process. will be pioneer among future molecular pathophysiology