Comparison of reproductive outcome, including the pattern of loss, between couples with chromosomal abnormalities and those with unexplained repeated miscarriages

• DOI: 10.1111/jog.12133
• Publication Date: 2013-09-05T08:32:40Z
• Authors: Helen Flynn; Junhao Yan; Sotirios H. Sarav...; Tin‐Chiu Li
• Keywords: Chromosomal Abnormality; Recurrent miscarriage; Products of conception

Abstract Aim Chromosomal abnormalities are an important cause of repeated miscarriage. Several studies have discussed the association between chromosomal and This study attempts to describe pattern miscarriage in this group women eventual pregnancy outcome couples with compared unexplained loss. Material Methods was a retrospective involving 795 miscarriages. Results Out couples, 28 (3.52%) were found abnormality (carrier group). Over half (65.5%) balanced reciprocal translocations. After referral, carrier had total 159 pregnancies, leading 36 live births (22.6%) among 18 couples. The after referral rate anomaly (55.6%) significantly ( P < 0.01) higher than that recurrent (28.1%). In anomaly, miscarriages more likely occur 6 12 weeks' gestation. Conclusions encouraging cumulative birth 64.3% for suggests further at natural conception viable option.