Reduced levels of actin gamma 1 predict poor prognosis in ovarian cancer patients

• DOI: 10.1111/jog.14353
• Publication Date: 2020-06-24T00:20:35Z
• Authors: Shiyan Chen; Xiaoxia Wang; Jin Yuan; Cui Deng; Xueman Xie; Jiali Kang
• Keywords: Tissue microarray

Abstract Aim To investigate the expression and function of actin gamma 1 (ACTG1) in ovarian cancer. Methods We performed immunohistochemical staining 176 cancer tissue samples a human microarray to detect ACTG1. Staining intensity was examined relation clinicopathological parameters. prognostic value ACTG1, ACTG1 mRNA data from 300 patients The Cancer Genome Atlas database were examined. Results results demonstrated that levels reduced examined, negatively correlated with various Levels also clinical stage. In Kaplan–Meier survival analysis, higher associated improved overall survival. multivariate analysis by Cox regression, identified as an independent marker favorable Conclusion may represent valuable for prognosis cancer, further studies are warranted.