Expression of extracellular matrix proteins nidogen‐1 and legumain in endometrial carcinomas

• DOI: 10.1111/jog.15158
• Publication Date: 2022-02-07T09:03:41Z
• Authors: Zeynep Bayramoglu; Ayse N. U. Kılınc; Ethem Omeroglu; Fatih Yilmaz; Denizhan Bayramoglu; Yasar Unlu; Hulya A. Aydin
• Keywords: Lymphovascular invasion

Our purpose was to comparatively investigate the expressions of nidogen-1 (NID1) and legumain (LGMN) in patients with endometrial cancer, intraepithelial neoplasia, proliferative endometrium.A cross-sectional, single-center study performed by obstetrics gynecology pathology departments our institution. The relationships between descriptive data, clinicopathologic information, immunohistochemical NID1 LGMN were investigated.The histological grades cancers (n = 124) as classified FIGO included 1 (41, 21.1%), 2 (48, 24.7%), 3 (35, 18.0%). medians ranges deep superficial 50.00 (0-285) 5.00 (0-100), respectively. intensity expression noted negative (30, 24.2%), mild (16, 12.9%), moderate (27, 21.8%), or strong (51, 41.1%). Median disease-free survival overall 75.00 (range: 170) months 77.00 months, Patients more intense displayed a higher grade. These likely have positive peritoneal cytology, larger tumor size, tendency for myometrial lymphovascular invasion, involvement ovaries, cervix, omentum, well lymph node metastasis, recurrence.Our data indicated that may important diagnostic implications pathologies. Further studies should be understand significance pathogenesis tumors.