Effect of chromosomal polymorphisms on the outcome of in vitro fertilization and embryo transfer

• DOI: 10.1111/jog.15732
• Publication Date: 2023-07-12T04:35:11Z
• Authors: Lixia Liang; Xiuping Zhang; Zhiping Zhang; Suming Xu; Yuanxia Wu; Xueluo Zhang; Xueqing Wu
• Keywords: Assisted Reproductive Technology; Embryo quality

The incidence of chromosomal polymorphisms (CP) is increased in infertile couples, but its impact on reproduction uncertain, especially undergoing assisted reproductive technology treatment. purpose the present study was to investigate effect CP outcomes vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) treatment METHODS: A total 1331 couples IVF/ICSI were involved this retrospective case-control study. participants divided into 4 groups according variations: (i) normal chromosomes (NC) group; (ii) (iii) both (BCP) and (iv) double (DCP) group. group further five subgroups: qh+, D/G, inv(9), Yqh+ Yqh-. IVF/ICSI-ET compared among groups.There no differences observed between eight terms number oocytes retrieved, MII rate, fertilization cleaved embryo quality rate for females males (p > 0.05). In male female, some subgroups experienced more oocyte retrieval operations achieve pregnancy than NC < rates live births significantly lower 0.05).In conclusion, ET affected by CP. It speculated that may be associated with chromosome polymorphism quality, although could not or determined morphological evaluation.