Identifying cardiovascular disease risk and outcome: use of the plasma triglyceride/high‐density lipoprotein cholesterol concentration ratio versus metabolic syndrome criteria

• DOI: 10.1111/joim.12036
• Publication Date: 2013-04-12T14:01:55Z
• Authors: M. R. Salazar; H. A. Carbajal; W. G. Espeche; M. Aizpurúa; C. E. Leiva Sisni...; C. E. March; E. Balbín; R. N. Stavile; G. M. Reaven
• Keywords: Adult; Aged, 80 and over; Male; Metabolic Syndrome; Adolescent; Incidence; Cholesterol, HDL; Argentina; Middle Aged; Prognosis; Risk Assessment; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Cardiovascular Diseases; Risk Factors; Prevalence; Humans; Female; Prospective Studies; Triglycerides; Aged; Follow-Up Studies

Abstract Background Metabolic syndrome (MetS) has been shown to predict both risk and CVD events. We have identified sex‐specific values for the triglyceride/high‐density lipoprotein cholesterol ( TG / HDL ‐C) ratio associated with an unfavourable cardio‐metabolic profile, but it is not known whether also predicts outcome. Methods To quantify outcomes a high TG/HDL‐C compare this that predicted using MetS, population longitudinal prospective observational study was performed in Rauch City, Buenos Aires, Argentina. In 2003 surveys were on random sample of 926 inhabitants. 2012, 527 women 269 men surveyed again search new The first event primary endpoint. Relative risks events between individuals above below cut‐points, or without estimated Cox proportional hazard. Main Outcome ‐C Results number subjects deemed at ‘high’ basis elevated (30%) having MetS (35%) relatively comparable. unadjusted hazard significantly increased when comparing versus ‘low’ groups no matter which criteria used, although somewhat higher those HR = 3.17, 95% CI :1.79–5.60 vs. 2.16, :1.24–3.75). However, difference essentially disappeared adjusted sex age 2.09, :1.18–3.72 2.01, :1.14–3.50 respectively). Conclusions An appears be just as effective diagnosis predicting development .