Standard and advanced echocardiographic study of patients with Paget's disease of bone: Evidence of a pagetic heart disease?

• DOI: 10.1111/joim.20069
• Publication Date: 2025-05-08T07:33:04Z
• Authors: Alfonso Giaquinto; Veronica Abate; Anita Vergatti; Riccardo Muscariello; Adelaide Iervolino; Martina Pucci; Guido Cavati; Filippo Pirrotta; Gianpaolo De Filippo; Roberta Esposito; Lanfranco D'Elia; Daniela Merlotti; Luigi Gennari; Domenico Rendina
• Keywords: Speckle tracking echocardiography; Interventricular septum

Abstract Background Paget's disease of the bone (PDB) is a metabolic disorder involving one or more skeletal sites. Cardiovascular diseases (CVDs) have been described in patients with PDB but not systematically analysed. Objectives This study aimed to compare standard and advanced (speckle‐tracking) echocardiographic parameters measured controls matched for age, weight, height history hypertension without disorders. Methods multicentre case–control included all referred Federico II Siena Universities, Italy, from March 2019 October 2022. During same time, we enrolled at least control each patient, sex, body mass index (BMI) hypertension. Results Sixty‐nine 115 healthy were this study. All treated zoledronic acid time diagnosis. Compared controls, on echocardiography, showed high prevalence aortic mitral valve calcifications and/or sclerosis, reduced left ventricular (LV) ejection fraction, stroke volume, cardiac output, increased interventricular septum thickness, posterior wall LV index, relative diastolic E / e ′ ratio systemic vascular resistance. Using speckle‐tracking lower global longitudinal strain myocardial work efficiency than controls. There was no relationship between activity extent severity abnormalities. Conclusion Overall, function structure impaired PDB. Additionally, associated early subclinical damage.