Clonal hematopoiesis of indeterminate potential and the risk of autoimmune diseases

• DOI: 10.1111/joim.20080
• Publication Date: 2025-03-12T00:10:17Z
• Authors: Hanzhang Wu; Jiahe Wei; Yuefeng Yu; Ningjian Wang; Xiao Tan

Clonal hematopoiesis of indeterminate potential (CHIP), characterized by the age-related expansion blood cells carrying preleukemic mutations, is associated with immune aging. This study aimed to investigate association between CHIP and established autoimmune diseases. We analyzed baseline data from 456,692 UK Biobank participants available whole-exome sequences. The primary outcome was 19 disorders. Associations among any (variant allele fraction ≥2%), large clones ≥10%), gene-specific subtypes incidence diseases were assessed using Cox regression. Mediation analysis performed explore role inflammation in link identified 17,433 11,970 at baseline. Participants 44% 43% higher risk for Crohn's disease, 25% 33% psoriasis, 13% 14% rheumatoid arthritis, 35% 55% vasculitis, respectively. status increased levels inflammatory markers, including white cell, platelets, neutrophils, neutrophil-to-lymphocyte ratio, overall mediation ratios 16.3% 7.1% 23.2% 7.2% vasculitis. an incident multiple diseases, potentially mediated elevated levels. Future research needed clarify mechanisms underlying these associations interventions reduce risk.