MR Diffusion Properties of Cervical Spinal Cord as a Predictor of Progression to Multiple Sclerosis in Patients with Clinically Isolated Syndrome

• DOI: 10.1111/jon.12808
• Publication Date: 2020-11-30T20:00:29Z
• Authors: Marek Dostál; Miloš Keřkovský; Jakub Stulík; Josef Bednařík; Petra Praksová; Monika Hulová; Yvonne Benešová; Eva Koriťáková; Andrea Šprláková‐...; Marek Mechl
• Keywords: Clinically isolated syndrome; Kurtosis

ABSTRACT BACKGROUND AND PURPOSE This study's aim was to investigate diffusion properties of the cervical spinal cord in patients with clinically isolated syndrome (CIS) through analysis tensor imaging (DTI) data and thereby assess capacity this technique for predicting progression CIS definite multiple sclerosis (CDMS). METHODS The study groups were comprised 47 (15 them CDMS within 2 years follow‐up) 57 asymptomatic controls. All controls had undergone magnetic resonance (MRI) spine including DTI brain MRI. Methodological approaches included histogram cord's parameters evaluation T2 hyperintense lesions brain. compared between groups. Sensitivity specificity calculations then performed a view conversion CDMS. RESULTS patient subgroups defined by differed significantly values fractional anisotropy (FA) kurtosis measured white matter (WM) normal‐appearing WM (NAWM). same also when healthy Receiver operating characteristic (ROC) revealed sensitivity FA NAWM 93% 72%, respectively, terms progression. CONCLUSION presents evidence that may be helpful