Interpretation of Brain Volume Increase in Multiple Sclerosis

• DOI: 10.1111/jon.12816
• Publication Date: 2020-12-13T22:39:15Z
• Authors: Tomas Uher; Niels Bergsland; Jan Krasensky; Michael G. Dwyer; Michaela Andelova; Lukas Sobisek; Eva Kubala Havrdova; Dana Horakova; Robert Zivadinov; Manuela Vaneckova
• Keywords: Clinical Significance

ABSTRACT BACKGROUND AND PURPOSE A high variability of brain MRI volume change measurement renders challenging its interpretation in multiple sclerosis (MS). Occurrence and clinical relevance observed apparent increase (BVI) MS patients have not been investigated yet. The objective was to quantify the prevalence factors associated with BVI. METHODS We examined 366 (2,317 scans) 44 controls (132 scans). Volumetric analysis changes performed by SIENA ScanView. BVI defined as >0%. compared characteristics without RESULTS found 26.3% (from 1,951) longitudinal scans (SIENA). If occurred, a probability that will be repeated consecutively more than or equal two times 15.9%. disease activity 50% cases. shorter time lower T2 lesion between scans, higher normalized (all P < .0001). proportion when analyzed ScanView (35.3%) (36.4% SIENA). CONCLUSIONS occurs great MR over short‐term follow‐up is stabilization. Although can caused several factors, results indicate error may contribute majority Clinicians should aware frequent occurrence BVI, interpret caution, use methods precise quantification changes.