Brain FDG‐PET findings in glutamic acid decarboxylase antibody‐associated epilepsy

• DOI: 10.1111/jon.12874
• Publication Date: 2021-05-06T21:36:05Z
• Authors: Neus Mongay‐Ochoa; Jacint Sala‐Padró; Gabriel Reynés‐Ll...; Laura Rodríguez‐Bel; Sònia Jaraba; Francisco Morandeira; Mercè Falip
• Keywords: Hippocampal sclerosis

Glutamic acid decarboxylase antibodies (GAD-Ab) are sometimes associated with chronic drug-resistant focal epilepsy. Clinically, it may manifest as mesial temporal lobe epilepsy (mTLE), GAD-Ab patients difficult to distinguish. Therefore, the aim of this study is compare brain metabolism mTLE and high serum titers (>2000 UI/ml) those hippocampal sclerosis (HS) confirmed GAD-ab negativity.Images from PET studies were normalized an SPM 12 template. Voxel voxel comparisons made using a two-sample one-tailed t-test.In both controls (mTLE-HS), hypometabolism in areas was observed. When comparing two groups, had statistically significant reduced insulae medial inferior frontal-hypothalamus area (p < 0.001).Hypometabolism together be characteristic GAD-ab. This pattern could useful diagnostic tool identify patients.