Brain FDG‐PET findings in glutamic acid decarboxylase antibody‐associated epilepsy

Hippocampal sclerosis
DOI: 10.1111/jon.12874 Publication Date: 2021-05-06T21:36:05Z
ABSTRACT
Glutamic acid decarboxylase antibodies (GAD-Ab) are sometimes associated with chronic drug-resistant focal epilepsy. Clinically, it may manifest as mesial temporal lobe epilepsy (mTLE), GAD-Ab patients difficult to distinguish. Therefore, the aim of this study is compare brain metabolism mTLE and high serum titers (>2000 UI/ml) those hippocampal sclerosis (HS) confirmed GAD-ab negativity.Images from PET studies were normalized an SPM 12 template. Voxel voxel comparisons made using a two-sample one-tailed t-test.In both controls (mTLE-HS), hypometabolism in areas was observed. When comparing two groups, had statistically significant reduced insulae medial inferior frontal-hypothalamus area (p < 0.001).Hypometabolism together be characteristic GAD-ab. This pattern could useful diagnostic tool identify patients.
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