Quantitative evaluation of brain iron accumulation in different stages of Parkinson's disease

• DOI: 10.1111/jon.12957
• Publication Date: 2021-12-14T10:02:59Z
• Authors: Kailyn R. Li; Josue Avecillas‐C...; Thanh D. Nguyen; Kelly M. Gillen; Alexey Dimov; Eileen Chang; Carly Skudin; Brian H. Kopell; Yi Wang; Alexander Shtilbans
• Keywords: Putamen; Quantitative Susceptibility Mapping; Caudate nucleus; Red nucleus

Abstract Background and Purpose Excessive brain iron deposition is involved in Parkinson's disease (PD) pathogenesis. However, the correlation of accumulation various nuclei not well‐established different stages disease. This cross‐sectional study aims to evaluate quantitative susceptibility mapping (QSM) as an imaging technique measure PD patients compared healthy controls. Methods Ninety‐six grouped by their Hoehn Yahr (H&Y) 31 controls were included this analysis. The magnetic values substantia nigra (SN), red nucleus (RN), caudate, putamen, globus pallidus obtained compared. Results Iron level was increased SN all versus ( p < .001), with no significant difference within stages. RN significantly stage II = .013) combined III IV .001). levels between any groups. Conclusions Our data suggest occurs early course only these patients. a large according H&Y staging. Prospective studies are warranted further validate QSM method follow iron, which could serve biomarker therapeutic target.