Transorbital sonography in idiopathic intracranial hypertension: Single‐center study, systematic review and meta‐analysis

• DOI: 10.1111/jon.13160
• Publication Date: 2023-10-12T06:39:31Z
• Authors: Eleni Bakola; Lina Palaiodimou; Andreas Eleftheriou; Katerina Foska; Anastasia Pikouli; Maria Stefanatou; Maria Chondrogianni; Georgios Velonakis; Elissavet Andreadou; Marianna Papadopo...; Theodoros Karapan...; Christos Krogias; Chrysa Arvaniti; Georgios Tsivgoulis
• Keywords: Single Center

Abstract Background and Purpose Transorbital sonography (TOS) provides a noninvasive tool to detect intracranial pressure by assessing optic nerve sheath diameter (ONSD) disc elevation (ODE). The utility of TOS in the diagnosis idiopathic hypertension (IIH) has been increasingly recognized. Methods A single‐center case‐control study sought compare TOS‐acquired ONSD ODE among IIH‐cases versus patients with other neurological diseases (controls). Furthermore, systematic review meta‐analysis was conducted present pooled mean differences diagnostic measures between controls. Results In study, consisting 31 34 sex‐ age‐matched controls, values were higher than controls ( p <.001), while more prevalent cases (65% vs. 15%; <.001). receiver‐operating characteristic (ROC)‐curve analysis revealed that optimal cutoff value for predicting IIH 5.15 mm, an area under curve (AUC) 0.914 (95% confidence interval [CI]: 0.861‐0.967) sensitivity specificity 85% 90%, respectively. 14 included studies 415 IIH‐cases, (mean difference 1.20 mm; 95% CI: 0.96‐1.44 mm 0.3 0.33‐0.67 mm). With regard ONSD, sensitivity, specificity, odds ratio calculated at 85.5% 77.9‐90.8%), 90.7% 84.6‐94.5%), 57.394 24.597‐133.924), AUC summary ROC‐curve 0.878 0.858‐0.899) point 5.0 mm. Conclusions high may deserve wider implementation everyday clinical practice.