Oral versus extra‐oral plasmablastic lymphoma: A comparative analysis of 101 cases

• DOI: 10.1111/jop.13269
• Publication Date: 2021-12-15T13:40:32Z
• Authors: Shabnum Meer; Yvonne Perner; Pascale Willem
• Keywords: Plasmablastic lymphoma; Oral Lichen Planus; Oral mucosa; Oral Cancers; BCL6

Originally described exclusively orally in HIV-infected patients, plasmablastic lymphoma (PBL) is increasingly extra and non-HIV-infected persons. The study comparatively analysed the clinico-pathologic features of oral PBLs (n = 55) to previously published extra-oral 45 + 1) diagnosed over a seven-year period at same institution an HIV prevalent setting South Africa order clarify any distinction between PBLs.Tumours were assessed histologically immunohistochemically with CD45 (LCA), CD3, CD20, CD79a, PAX5, CD138, MUM1, BLIMP1, VS38c, Ki-67, BCL6 CD10 using standard protocols. Age ranged from 22 76 years (oral) 9 59 (extra-oral). Most PBL patients positive [oral (84%); (65%)]. Male:female ratio was 2.7:1 for 1.4:1 PBLs. Favoured sites maxilla anus. displayed indistinguishable immunohistochemical profile unusually high expression (oral: 98%, extra-oral: 84%). EBV by chromogenic situ hybridisation (ISH) showed positivity all 95% MYC rearrangements (fluorescence ISH break-apart probe) similar PBLs.Extra-oral identical its counterpart gender age distribution, status, morphological appearances, immunophenotypic association. should be regarded as tumour irrespective or site origin.