Ligature‐induced peri‐implantitis in mice

• DOI: 10.1111/jre.12234
• Publication Date: 2014-09-20T09:39:21Z
• Authors: F. Q. Pirih; S. Hiyari; A. D. V. Barroso; A. C. A. Jorge; J. Perussolo; E. Atti; S. Tetradis; P. M. Camargo
• Keywords: Peri-implantitis; Ligature; Histology; Granulation tissue; Alveolar process

Background and Objective Peri‐implantitis has a prevalence of 11–47%, involves destruction peri‐implant bone may lead to implant loss. A detailed understanding the pathogenesis peri‐implantitis is lacking. The objective this study was develop murine model experimental peri‐implantitis. Material Methods Machined, smooth‐surface, screw‐shaped titanium implants were placed in healed alveolar left maxillary molars C57 BL /6J male mice, 8 wk after tooth extraction. induced by securing silk ligatures around head fixtures. Implant survival levels analyzed micro‐computed tomography (micro‐ CT ) scans histology, 12 ligature placement. Results 60% (six 10) for with 100% (eight eight) controls. Micro‐ revealed significantly greater loss that received survived, compared radiographic findings confirmed via histology toluidine blue staining. Conclusion This describes edentulous bone. should be useful tool dissect pathogenic mechanisms evaluate potential treatment interventions.