Steatosis caused by experimental periodontitis is reversible after removal of ligature in rats

• DOI: 10.1111/jre.12459
• Publication Date: 2017-05-15T11:08:51Z
• Authors: J. dos Santos Car...; A. C. Cardoso Gui...; E. Herlany Pereir...; A. dos Santos Car...; F. R. P. da Silva; L. F. de Carvalho...; A. de Pádua Rocha...; D. Di Lenardo; L. K. M. de Souza; A. L. dos R. Barbosa; J.‐V. R. Medeiros; J. S. de Oliveira; D. F. P. Vasconcelos
• Keywords: Malondialdehyde; Steatosis

Background and Objective Periodontitis may promote harmful systemic effects such as changes in hepatic tissues. The purpose of this study was to investigate whether the steatosis oxidative stress caused by experimental periodontitis are reversible liver. Material Methods Twenty‐four rats were divided into three groups: control, P20‐20 (20 days with 20 without periodontitis, verify reversibility injuries). following parameters assessed: gingival bleeding index, probing pocket depth, myeloperoxidase activity, alveolar bone loss for periodontal tissues; liver weights, histopathological scores steatosis, inflammation necrosis liver; glutathione, malondialdehyde, total cholesterol triglyceride concentrations blood levels aspartate aminotransferase, alanine albumin, gamma‐glutaryl transferase, random glucose. Results Gingival index , depth demonstrated development periodontitis. There a significant reduction score animals from group when compared group. presented significantly higher glutathione (11 times) lower malondialdehyde (nearly 23%), (both tissue) For aminotransferase transferase glucose, difference between groups not observed. Conclusion Our results demonstrate that microvesicular is after removal ligature, which associated increase lipid peroxidation