Microbiome and Inflammatory Biomarkers Associated With Palatal Wound Healing

• DOI: 10.1111/jre.13373
• Publication Date: 2025-01-13T10:05:38Z
• Authors: Mauro Pedrine San...; Ingrid Fernandes ...; Ana Carolina Ferr...; Octavio A. Gonzalez; Sreenatha Kirakodu; Mabelle de Freita...; Renato Corrêa Via...; Luciana Macchion ...; Manuela Maria Via...
• Keywords: Oral mucosa; Exudate; Oral Microbiome

ABSTRACT Aim The clinical outcomes of a variety surgical procedures highly depend on tissue repair and show high variability among patients. There is gap in the literature how host inflammatory response, microbiome, interplay between them can influence oral mucosa healing. In this pilot study, we aimed to evaluate microbiome biomarkers profiles patients who had desired versus undesired wound healing palatal mucosa. Methods Seventeen underwent free gingival graft (FGG) for socket preservation. Palatal closure (WC) epithelization (EPT) were assessed clinically. Biofilm from was collected before procedure 3, 7, 14, 30 days postoperatively. exudate sampled Days 3 7. At 14 posttreatment, classified into two groups based EPT rates: (1) (UH) (2) (DH). Results No difference observed alfa diversity over time or groups. beta diversity, both UH DH showed changes 3–7 respectively, compared with baseline ( p = 0.01), returning its initial condition later. trend toward different profile Day 7 0.08). Bacterium composition balance healthy species pathogens time, whereas characterized by microorganisms correlated epithelium invasion/cytotoxicity; virulence factor upregulation; diseases, such as periodontitis aphthous stomatitis, until 30. an increase IL‐6, MCP‐1, MIP‐1α decrease TIMP‐1, IL‐1β, MIP‐1α. On MMP‐2 greater concentrations intergroup assessment, MCP‐1 increased UH. Conclusion Specific microbiome/inflammatory are associated Trial Registration: NCT05171400