Circadian variation of metabotropic glutamate receptor 5 availability in the rat brain

• DOI: 10.1111/jsr.12432
• Publication Date: 2016-06-30T05:26:44Z
• Authors: David Elmenhorst; Kristina Mertens; Tina Kroll; Angela Oskamp; Johannes Ermert; Eva‐Maria Elmenhorst; Franziska Wedekind; Simone Beer; Heinz H. Coenen; Andreas Bauer
• Keywords: Putamen

Summary The metabotrophic subtype 5 glutamate receptor ( mG luR5) plays a critical role in synaptic plasticity besides its involvement numerous neurological disorders, such as depression. As luR5 availability humans is altered sleep deprivation, we hypothesized that underlies circadian variation. To investigate whether potential changes measured density randomized fashion at six different daytimes 11 adult Sprague–Dawley rats. was quantified by positron emission tomography PET ) using the radioactive ligand [ C] ABP 688. 688 uptake nine regions of interest with reference tissue model. Significant differences binding BP ND and therefore between times were found cortex, cingulate amygdala, caudate putamen nucleus accumbens. Further post‐hoc statistical analysis (Tukey–Kramer test) time‐points revealed significant 07:00 hours (start light‐on phase) 15:00 (last time‐point putamen. This study shows increased during light‐on, or phase, rodents approximately 10%. Given densities play psychiatric further investigation warranted to evaluate their mood humans.