Human blood adenosine biomarkers and non‐rapid eye movement sleep stage 3 (NREM3) cortical functional connectivity associations during a 30‐day head‐down‐tilt bed rest analogue: Potential effectiveness of a reactive sledge jump as a countermeasure

• DOI: 10.1111/jsr.13323
• Publication Date: 2021-04-08T06:20:17Z
• Authors: Christiane M. Nday; Christos A. Frant...; Christina Plomariti; Sotiria C. Gilou; Giorgos Ntakakis; Graham Jackson; Lykourgos Chatzii...; Panagiotis D. Bam...; Chrysoula Kourtid...
• Keywords: Postcentral gyrus

Summary We investigated the alterations of sleep regulation and promotion biomarkers as adenosine through its enzymes total deaminase (tADA)/adenosine (ADA2) in a microgravity analogue environment head‐down‐tilt bed rest their association with brain connectivity networks during non‐rapid eye movement stage 3 (NREM3), well effectiveness reactive sledge (RSL) jump countermeasure to promote sleep. A 23 healthy male volunteers were maintained 6° position for 30 days assigned either control or RSL group. Blood collection polysomnographic recordings performed on data acquisition day 1, 14, −14, 21, respectively. Immunochemical techniques network‐based statistics employed cortical estimation. Our findings indicate that human blood NREM3 functional are impaired simulated microgravity. physical activity intervened quality via tADA/ADA2 fluctuations lack, minor increases, limited degree node resting‐state networks. Statistically significant decreases involving regions (left superior temporal gyrus, right postcentral precuneus, left middle frontal angular gyrus precuneus) auditory, sensorimotor default‐mode executive highlight disturbances due sleep‐promoting role countermeasure. The led deterioration projected or/and shift. This decline was more pronounced absence countermeasure, thereby highlighting likely exploitation space missions.