The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm

• DOI: 10.1111/jvh.12248
• Publication Date: 2014-04-09T03:41:29Z
• Authors: H. Razavi; I. Waked; C. Sarrazin; R. P. Myers; R. Idilman; F. Calinas; W. Vogel; M. C. Mendes Correa; C. Hézode; P. Lázaro; U. Akarca; S. Aleman; İ. Balık; T. Berg; F. Bihl; M. Bilodeau; A. J. Blasco; C. E. Brandão Mello; P. Bruggmann; M. Buti; J. L. Calleja; H. Cheinquer; P. B. Christensen; M. Clausen; H. S. M. Coelho; M. E. Cramp; G. J. Dore; W. Doss; A. S. Duberg; M. H. El‐Sayed; G. Ergör; G. Esmat; K. Falconer; J. Félix; M. L. G. Ferraz; P. R. Ferreira; S. Frankova; J. García‐Samaniego; J. Gerstoft; J. A. Giria; F. L. Gonçales; E. Gower; M. Gschwantler; M. Guimarães Pessôa; S. J. Hindman; H. Hofer; P. Husa; M. Kåberg; K. D. E. Kaita; A. Kautz; S. Kaymakoglu; M. Krajden; H. Krarup; W. Laleman; D. Lavanchy; R. T. Marinho; P. Marotta; S. Mauss; C. Moreno; K. Murphy; F. Negro; V. Nemecek; N. Örmeci; A. L. H. Øvrehus; J. Parkes; K. Pasini; K. M. Peltekian; A. Ramji; N. Reis; S. K. Roberts; W. M. Rosenberg; F. Roudot‐Thoraval; S. D. Ryder; R. Sarmento‐Castro; D. Semela; M. Sherman; G. E. Shiha; W. Sievert; J. Sperl; P. Stärkel; R. E. Stauber; A. J. Thompson; P. Urbanek; P. Van Damme; I. van Thiel; H. Van Vlierberghe; D. Vandijck; H. Wedemeyer; N. Weis; J. Wiegand; A. Yosry; A. Zekry; M. Cornberg; B. Müllhaupt; C. Estes
• Keywords: Male; diagnosis; 3207 Medical Microbiology; 32 Biomedical and Clinical Sciences; ddc:616.07; Global Health; anzsrc-for: 1103 Clinical Sciences; Hepatitis; disease burden; 0302 clinical medicine; Models; 80 and over; Prevalence; 2.2 Factors relating to the physical environment; Chronic; Child; ddc:616; Aged, 80 and over; treatment; Liver Disease; Incidence; 3 Good Health and Well Being; Statistical; Middle Aged; Hepatitis C; 3. Good health; Infectious Diseases; 5.1 Pharmaceuticals; Child, Preschool; Combination; HCV; epidemiology; Drug Therapy, Combination; Female; Infection; Adult; Adolescent; Chronic Liver Disease and Cirrhosis; prevalence; 610; Antiviral Agents; Young Adult; 03 medical and health sciences; anzsrc-for: 32 Biomedical and Clinical Sciences; Hepatitis - C; Drug Therapy; 616; Humans; Preschool; anzsrc-for: 3207 Medical Microbiology; Aged; Models, Statistical; Infant, Newborn; 940; Infant; Hepatitis C, Chronic; Newborn; mortality; Emerging Infectious Diseases; anzsrc-for: 0605 Microbiology; incidence; hepatitis C; Digestive Diseases

SummaryThe disease burden of hepatitis C virus (HCV) is expected to increase as the infected population ages. A modelling approach was used to estimate the total number of viremic infections, diagnosed, treated and new infections in 2013. In addition, the model was used to estimate the change in the total number of HCV infections, the disease progression and mortality in 2013–2030. Finally, expert panel consensus was used to capture current treatment practices in each country. Using today's treatment paradigm, the total number of HCV infections is projected to decline or remain flat in all countries studied. However, in the same time period, the number of individuals with late‐stage liver disease is projected to increase. This study concluded that the current treatment rate and efficacy are not sufficient to manage the disease burden of HCV. Thus, alternative strategies are required to keep the number of HCV individuals with advanced liver disease and liver‐related deaths from increasing.