Predictive value of serum actin‐free Gc‐globulin for complications and outcome in acute liver failure

• DOI: 10.1111/jvh.12259
• Publication Date: 2014-04-29T03:42:56Z
• Authors: A. Bagchi; S. Kumar; P. C. Ray; B. C. Das; P. K. Gumma; P. Kar
• Keywords: Vitamin D-binding protein

Summary This prospective study was designed to evaluate whether early changes in actin‐free G c‐globulin levels were associated with complications and outcomes identify factors persistent low acute liver failure ( ALF ). Thirty‐two consecutive patients admitted from O ctober 2011 D ecember 2012 followed up until death or complete recovery. All had serum estimation at admission day three expiry. Logistic regression analysis performed independent predictors of mortality. A receiver operating characteristic curve also performed. Nonsurvivors significantly lower median than survivors (87.32 vs 180 mg/L; P < 0.001). revealed an area under AUC ) 0.771 showed that level ≤124 mg/L would predict mortality 92% sensitivity 71.4% specificity. Patients decreasing trend found have more developed complications. c‐globulin, total leucocyte count creatinine Incorporating these variables, a score predicting risk derived. The scoring system compared MELD K ing's C ollege riteria as individual predictor Serum presentation is predictive outcome can be used for stratification. Its low‐level predicts correlated various