Comparison of Serum Concentrations of Symmetric Dimethylarginine and Creatinine as Kidney Function Biomarkers in Cats with Chronic Kidney Disease

• DOI: 10.1111/jvim.12445
• Publication Date: 2014-09-17T15:32:36Z
• Authors: J.A. Hall; M. Yerramilli; E. Obare; M. Yerramilli; D.E. Jewell
• Keywords: Asymmetric dimethylarginine

Symmetric dimethylarginine (SDMA) has been shown to be an accurate and precise biomarker for calculating estimated glomerular filtration rate (GFR) in humans, as well a more sensitive than serum creatinine concentration (sCr) assessing renal dysfunction.The purpose of this retrospective study was report on the utility measuring SDMA concentrations cats detection chronic kidney disease (CKD) before diagnosis by conventional measurement sCr.Chronic (n = 21) included those persistently azotemic ≥3 months 15), nonazotemic with GFR >30% decreased from median normal 4), calcium oxalate stones 2). Healthy geriatric were selected same colony.Symmetric (liquid chromatography-mass spectroscopy) sCr (enzymatic colorimetry) determined retrospectively historical data or banked samples at time (iohexol clearance) measured cats.Serum (r -0.79) -0.77) significantly correlated (both P < .0001). became increased 17/21 (mean, 17.0 months; range, 1.5-48 months). Serum had higher sensitivity (100%) compared (17%), but lower specificity (91% versus 100%) positive predictive value (86% 100%).Using CKD allows earlier sCr, which may desirable initiating renoprotective interventions that slow progression CKD.