Fractional excretion of electrolytes in volume‐responsive and intrinsic acute kidney injury in dogs: Diagnostic and prognostic implications

• DOI: 10.1111/jvim.15146
• Publication Date: 2018-05-17T09:51:55Z
• Authors: Roberta Troìa; Marta Gruarin; Chiara Grisetti; Federica Serafini; Luca Magna; Erika Monari; Massimo Giunti; Francesco Dondi
• Keywords: Case fatality rate

The value of fractional excretion (FE) electrolytes to characterize and prognosticate acute kidney injury (AKI) is poorly documented in dogs.To evaluate the diagnostic prognostic roles FE dogs with AKI.Dogs (n = 135) AKI treated standard care (February 2014-December 2016).Prospective study. Clinical laboratory variables including electrolytes, were measured upon admission. Dogs graded according AKI-IRIS guidelines grouped features (volume-responsive, VR-AKI; intrinsic, I-AKI) outcome (survivors/non-survivors). Group comparison regression analyses hazard ratios (HR) evaluation for I-AKI mortality performed. P < .05 was considered significant.Fifty-two 135 (39%) had VR-AKI, 69/135 (51%) 14/135 (10%) unclassified. significantly higher example, sodium (FENa, %) 2.39 (range 0.04-75.81) than VR-AKI ones 0.24 0.01-2.21; .001). Overall, case fatality 41% (55/135). Increased detected nonsurvivors, FENa 1.60 0.03-75.81) compared survivors 0.60 0.01-50.45; .004). Several risk factors death identified, grade (HR 1.39, .002), 1.03, .001), urinary output 5.06, .001).Fractional performed well early differentiation between I-AKI, related outcome, could be useful tools manage clinical practice.