Behavior in dogs with spontaneous hypothyroidism during treatment with levothyroxine

• DOI: 10.1111/jvim.15342
• Publication Date: 2018-11-30T08:50:23Z
• Authors: Alenka Hrovat; Tiny De Keuster; Hans S. Kooistra; Luc Duchateau; Mark A. Oyama; Kathelijne Peremans; Sylvie Daminet
• Keywords: Levothyroxine

Background Thyroid hormone supplementation anecdotally has been described as a valid treatment option for dogs with aggression‐related problems. However, prospective, controlled, and blinded trials evaluating behavior neurohormonal status in hypothyroid during levothyroxine are lacking. Objective Levothyroxine will have significant influence on the of spontaneous hypothyroidism. Animals Twenty client‐owned diagnosed Methods This prospective study was to evaluate dogs, which screened at initial presentation, after 6 weeks, months (starting dosage 10 μg/kg PO q12h) using standardized Canine Behavioral Assessment Research Questionnaire ( C‐BARQ). At each time period, circulating serotonin prolactin (PRL) concentrations were evaluated commercially validated ELISA kit heterologous radioimmunoassay, respectively. Results After weeks thyroid supplementation, C‐BARQ scores demonstrated increase activity P < .01). No change any behavioral signs observed treatment. difference > .99 = .46) PRL .37) noted between 6‐week 6‐month periods compared baseline. Conclusions Clinical Importance The results this indicate increased supplementation. None cohort showed