Evaluation of duodenal perfusion by contrast‐enhanced ultrasonography in dogs with chronic inflammatory enteropathy and intestinal lymphoma

• DOI: 10.1111/jvim.15432
• Publication Date: 2019-02-20T05:11:20Z
• Authors: Khoirun Nisa; Sue Yee Lim; Masayoshi Shinohara; Tatsuyuki Osuga; Nozomu Yokoyama; Masahiro Tamura; Noriyuki Nagata; Kazuyoshi Sasaoka; Angkhana Dermlim; Rommaneeya Leela‐...; Tomoya Morita; Noboru Sasaki; Keitaro Morishita; Kensuke Nakamura; Hiroshi Ohta; Mitsuyoshi Takiguchi
• Keywords: Male; Lymphoma; Duodenum; Iron; Contrast Media; Ferric Compounds; Severity of Illness Index; 0403 veterinary science; Dogs; Duodenal Neoplasms; Animals; Dog Diseases; enhancement; Ultrasonography; tissue perfusion; Oxides; 04 agricultural and veterinary sciences; Inflammatory Bowel Diseases; intestinal diseases; 3. Good health; Cross-Sectional Studies; Area Under Curve; Pulsatile Flow; 649; CEUS; Female; SMALL ANIMAL; Blood Flow Velocity

Background Contrast‐enhanced ultrasonography (CEUS) can be used to evaluate intestinal perfusion in healthy dogs. It is helpful for diagnosing and monitoring inflammatory bowel disease humans could useful dogs with chronic diseases. Objectives To examine duodenal enteropathy (CIE) lymphoma. Animals Client‐owned CIE (n = 26) or lymphoma 7) gastrointestinal signs but histopathologically normal duodenum (controls, n 14). Methods In this cross‐sectional study, were classified into remission 16) symptomatic 10) groups based on clinical scores determined at the time of CEUS. The was scanned after IV injection Sonazoid® (0.01 mL/kg). CEUS‐derived parameters, including time‐to‐peak, peak intensity (PI), area under curve (AUC), wash‐in wash‐out rates evaluated. Results PI significantly higher group (median (range); 105.4 (89.3‐128.8) MPV) than control (89.9 (68.5‐112.2) MPV). AUC (4847.9 (3824.3‐8462.8) MPV.sec) (3448.9 (1559.5‐4736.9) (3862.3 (2094.5‐6899.0) groups. score positively correlated group. No significant differences parameters detected between Conclusions Clinical Importance detect inflammation hence are potentially excluding a diagnosis CIE.