Effect of radiotherapy on freedom from seizures in dogs with brain tumors

• DOI: 10.1111/jvim.15695
• Publication Date: 2020-02-07T17:40:16Z
• Authors: Susana R. Monfort...; John H. Rossmeisl; Jason Russell; Mark A. Holmes; Annette Wessmann; Jo Morris; Jane M. Dobson; An E. Vanhaesebrouck
• Keywords: Brain tumor

Abstract Background Seizures are a common presenting sign in dogs with brain tumors. Hypothesis/Objectives To investigate the effect of radiotherapy on freedom from tumor‐associated seizures and survival time dogs. Animals Thirty‐two client‐owned seizures; 18 received medical treatment radiotherapy, 14 alone. Methods Multicenter retrospective study. Baseline characteristics (seizure semiology, magnetic resonance imaging [MRI] characteristics, treatment) duration seizure were recorded for 2 groups. Duration between groups was compared (log‐rank test) using Cox's proportional hazard analysis, baseline entered as covariates. Results The significantly longer group ( P < .001), mean 24 months (95% confidence interval [CI], 14.3‐33.8) versus 1.7 control CI, 0.5‐2.9) 34.6 CI: 25.2‐44.1) 6.2 2.6‐9.7) respectively. not associated after start treatment. In group, 5 euthanized during study period because causes other than seizures. recurrence observed before death all Conclusions Clinical Importance A tumors to only. pathophysiological mechanisms epileptogenesis radiation therapy unclear date. Further prospective studies needed.