Hepatic lead and copper concentrations in dogs with chronic hepatitis and their relationship with hematology, serum biochemistry, and histopathology

• DOI: 10.1111/jvim.16149
• Publication Date: 2021-05-22T08:40:18Z
• Authors: Eleonora Gori; Alessio Pierini; Valentina Meucci; Francesca Abramo; Luisa V. Muscatello; Veronica Marchetti
• Keywords: Microcytosis; Hepatic fibrosis; Histopathology; Hematology; Chronic hepatic

Although the influence of copper ([Cu]) on chronic hepatitis (CH) has been widely studied in dogs, little information is available about accumulation other metals.We assessed concentration lead ([Pb]) livers dogs with CH or without abnormal hepatic [Cu] to establish if any association existed between [Pb] and either hematologic biochemical variables, fibrosis, necrosis inflammation liver histology.Thirty-four that had determined.Retrospective review medical records [Pb]. Chronic was defined using current American College Veterinary Internal Medicine consensus statement guidelines. Hepatic were determined square wave anodic stripping voltammetry. Dogs divided into 2 groups based [Cu]: <400 ppm (LoCu) ≥400 (HiCu).The median 357 (range, 100-7743 ppm) 58.7 6.89-224.4 ppm), respectively. Nineteen LoCu 15 HiCu. Median significantly higher HiCu compared (P < .001). correlated (rho = 0.7; P microcytosis than did normal red cell volume .02). not necroinflammatory fibrosis scores.Although additional studies are needed better understand clinical role [Pb], may also have In addition, high be present.