Pharmacokinetics of isavuconazole in healthy cats after oral and intravenous administration

• DOI: 10.1111/jvim.16452
• Publication Date: 2022-05-26T10:20:16Z
• Authors: Dennis J. Woerde; Luke A. Wittenburg; Jonathan D. Dear
• Keywords: Tolerability

Isavuconazole is a triazole antifungal drug that has shown good efficacy in human patients. Absorption and pharmacokinetics have not been evaluated cats.To determine the of isavuconazole cats given single IV or PO dose.Eight healthy, adult research cats.Four received 100 mg capsules PO. Four 5 mg/kg solution IV. Serum was collected at predetermined intervals for analysis using ultra-high performance liquid chromatography-tandem mass spectrometry. Data were analyzed 2-compartment uniform weighting pharmacokinetic with lag time administration 2 compartment, 1/y2 administration. Predicted 24 48-hour dosing administered modeled vitro plasma protein binding assessed.Both resulted high serum concentrations. Intravenous formulations appear to be able used interchangeably. Peak concentrations occurred ± 3.8 hours after an elimination rate half-life 66.2 55.3 hours. Intersubject variability apparent both groups. Two vomited 6 8 No adverse effects observed group. Oral bioavailability estimated approximately 88%. calculated 99.0% 0.03%.Isavuconazole might prove useful fungal disease its favorable pharmacokinetics. Additional studies on safety, efficacy, tolerability long-term use are needed.