A novel meningioma with tyrosine‐rich crystals in a 6‐year‐old Great Dane

• DOI: 10.1111/jvim.16789
• Publication Date: 2023-06-14T05:20:54Z
• Authors: Kara Majors; Savannah M. Rocha; Rebecca Windsor; Ronald B. Tjalkens; Julia Engelien; Tawfik Aboellail
• Keywords: 0403 veterinary science; neoplasia; atypical; Veterinary medicine; dog; SF600-1100; SMALL ANIMAL; 04 agricultural and veterinary sciences; frontal; brain tumor; crystal

AbstractA 6‐year‐old female spayed Great Dane was evaluated for acute onset cluster seizures. Magnetic resonance imaging (MRI) identified a mass in the olfactory bulbs with a large mucoid component caudal to the primary mass. The mass was removed via transfrontal craniotomy and histopathology revealed a tyrosine crystalline‐rich, fibrous meningioma with a high mitotic index. Repeat MRI at 6 months showed no detectable tumor regrowth. The dog is clinically normal with no seizures at the time of publication 10 months after surgery. This meningioma subtype is rare in humans. This unique meningioma occurred in a dog of younger age and uncommon breed for intracranial meningioma. Biological progression of this tumor subtype is unknown; however, growth rate might be slow despite the high mitotic index.